Differin Gel (adapalene 0.1%) has the power of a prescription, yet it has the first and only OTC topical retinoid acne treatment. Differin ® Gel, containing adapalene, is used for the topical treatment of acne vulgaris. Each gram of Differin Gel contains adapalene 0.1% (1 mg) in a vehicle consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water and sodium hydroxide. What is Differin? How Does it Work? Differin Gel (adapalene 0.1%) is the first and only retinoid available OTC for the treatment of acne. A retinoid is simply a derivative of vitamin A. Not your parents’ acne treatment. Take a different approach to clearing—and preventing—your acne. Non-comedogenic, fragrance-free Differin Gel contains the retinoid adapalene, the first over-the-counter active ingredient for acne in more than 30 years. Differin Gel contains a Rx-strength acne-fighting retinoid. It clears breakouts where they start (deep in the pores), prevents acne before it begins, and as a result, restores skin’s texture and tone. Compare prices and find coupons for Differin Gel at more than 60,000 US pharmacies. Save up to 80% instantly! Differin Gel - First ever FDA approved product to contain a prescription strength acne- fighting retinoid Adapalene, without prescription. Contains 0.1% Adapalene, the only multi-benefit dermatologist recommended retinoid available without a prescription. DIFFERIN® Gel, containing adapalene, is used for the topical treatment of acne vulgaris. Each gram of DIFFERIN® Gel contains adapalene 0.1% (1 mg) in a vehicle consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water and sodium hydroxide. May 3. How to use Differin. Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Differin is only intended for use in adults and adolescents aged 12 years and over. DIFFERIN (adapalene) Gel, 0.3% contains adapalene 0.3% (3 mg/g) in a topical aqueous gel for use in the treatment of acne vulgaris, consisting of carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water, and sodium hydroxide. May contain hydrochloric acid for pH.